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Healthy drinking has some effect in helping people to abstain from alcohol or to moderate their use, however it is not as effective with alcohol as with opiates because alcohol affects many different neurotransmitters. The downside of naltrexone is that the body's natural painkillers, the endorphins, are unable to do their job when it is present. People taking naltrexone are advised to wear medic-alert bracelets so that doctors will know that painkillers are ineffective on these people.

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